【摘要】 【目的】通过检测血液及腹腔液中生殖内分泌激素水平 ,了解内分泌因素在子宫内膜异位症所致不孕中的作用。【方法】运用荧光微粒子发光法 (MEIA) ,于卵泡期对 78例不孕或子宫内膜异位症 (EM)患者 (EM合并不孕 32例 ,单纯EM者2 0例 ,单纯不孕者 2 6例 )及 14名健康绝育者的血液及腹腔液进行生殖内分泌激素的检测。【结果】EM者血中催乳素(PRL)、雌二醇 (E2 )及睾酮 (T)水平高于无EM者 (P <0 0 5 ) ,EM合并不孕者PRL及T高于EM非不孕者 ;重度EM的PRL、E2及T高于中度和轻度EM (P <0 0 5 ) ;无EM的不孕者除LH较正常对照组高外 ,其余与正常对照组之间无差异 ;卵泡刺激素 (FSH)及孕酮 (P)水平在以上各组之间无差异 (P >0 0 5 )。EM合并不孕组腹腔液中PRL、LH、E2及T水平高于其他各组 (P <0 0 5 ) ,而FSH及P与其他各组之间无差异 (P >0 0 5 )。EM非不孕者PRL高于非EM不孕及正常对照组 (P<0 0 5 )、LH则与正常对照组无差异 ,但低于非EM不孕组 (P <0 0 5 ) ,而FSH、E2及P与非EM不孕及正常对照组间无差异 (P >0 0 5 ) ;非EM不孕组与正常对照组之间除LH较高外 ,其余各项无差异 ;不同程度EM组之间除FSH无差异外 ,其余各项均有差异 ,重度高于中度 ,中度又高于轻度EM (P <0 0 5 )。【结论】子宫内膜异位症特别更多还原

【Abstract】 To identify the role of reproductive endocrinology on infertility caused by endometriosis(EM) by detecting reproductive hormones in blood and peritoneal fluid. During follicular phase,reproductive hormones in blood and peritoneal fluid were measured by MEIA in 78 patients(32 infertile women with pelvic EM, of whom 19 cases had abnormal menstruation, 20 women with EM only and 26 infertile women with uncertain causes).The control group were 14 healthy women who underwent tubal ligation. The levels of PRL?E2 and T in blood were higher in patients with EM than in infertile women without EM and in the control group, these hormones were higher in severe cases of EM than in moderate and mild cases(P<0 05); the levels of PRL and T were higher in EM patients with infertility than in those patients without infertility;the level of LH was higher in infertile women without EM than in the control group(P<0 05); there was no difference in the levels of FSH and P in blood among all groups(P>0 05).The levels of PRL?LH?E2 and T in peritoneal fluid were higher in infertile patients with EM than in the other groups(P<0 05),but there was no difference in the levels of FSH and P between them(P>0 05). The level of PRL was higher in EM patients without infertility than in infertile women without EM and in normal control, but LH was higher in infertile women without EM than in EM patients without infertility and in normal control(P<0 05). There was no difference in the levels of FSH?E2 and P among these three groups(P>0 05). All hor mones except FSH appeared higher in severe cases than in moderate cases, and higher in moderate than in mild cases(P<0 05). [Conclusion] Endometriosis patients especially those with infertility have higher levels of PRL and T in blood and peritoneal fluid which may be one of the causes of infertility.更多还原