【摘要】 目的 探讨冠心病猝死病例的死因诊断方法。方法 应用LSAB法对22例疑诊为冠心病猝死病例的心肌细胞进行纤维连接蛋白、肌动蛋白及肌红蛋白的免疫组化研究,并以15例非心性死亡病例作对照。结果 22例冠心病猝死可疑病例心肌中,纤维连接蛋白染色,20例呈阳性,2例阴性;肌动蛋白染色,15例明显缺失,5例轻度缺失,2例无缺失;肌红蛋白染色,13例明显缺失,6例轻度缺失,3例无缺失。15例非心性死亡阴性对照病例,纤维连接蛋白均呈阴性,肌动蛋白及肌红蛋白均无缺失。结论 心肌细胞免疫组化检测是冠心病猝死病例死因诊断的有效手段。更多还原

【Abstract】 Objective To study the diagnostic method for cause of death of sudden coronary heart disease (SCD) . Method Immunohistochemical study of fibronecrin (FN), actin and myoglobin (Mb) was performed on the hearts from 22 cases of SCD and 15 cases of non - cardiac death controls with LSAB - method. Result FN was postitive in myocardium in 20 cases of SCD, but negative in 2 of SCD and in all 15 non - cardiac death controls.There were marked deletion of action in myocardium from 15 cases of SCD, and slight deletion in 5 of SCD, and no deletion in 2 of SCD and in all 15 not)- cardiac death controls.There were marked deletion of Mb in myocardium from 13 cases of SCD, and slight deletion in 6 of SCD, and no deletion in 3 of SCD and in all 15 non - cardiac death controls. Conclusion Inununohistochemical detection in myocardium is a effective approach for studying the causes of death of SCD.更多还原