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医院制剂中应用旋光法对青、链霉素皮试液的质量控制和稳定性预测

Quality control of the liquid skin-test preparations of penicillin and streptomycin and the prediction of their stability by spectropolarimetry method

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【作者】 李淑芳冯文虹郭华

【Author】 LI Shu fang,FENG Wen hong,GUO HuaDepartment of Pharmacy, China Japan Friendship Hospital,Beijing,100029

【机构】 中日友好医院药学部!北京100029

【摘要】 目的 :用旋光法替代常规方法 ,对青、链霉素皮试液进行含量测定。方法 :采用旋光法测定青、链霉素皮试液的含量 ,用初匀速法预测其稳定性。结果 :青、链霉素皮试液的旋光度与溶液浓度呈良好线性关系 (r =0 .9997) ,且回收率好 ;4℃下青霉素皮试液贮存期为 5d ,链霉素皮试液贮存期为 179d。结论 :旋光法可替代常规方法用于青、链霉素皮试液的含量测定。

【Abstract】 Objective:To measure the content of penicillin and streptomycin in the liquid shin test preparetions and to predict their stability.Methods:Spectropolarimetry was adopted to measure the content of penicillin and streptomycin in the liquid shin test preparation and the initial uniform velocity method was adopted to predict their stability.Results:The spectropolar activity of the liquid skin test preparations of penicillin and streptomycin and the solution concentration showed a good linear relationship( r =0.9997),and the recovery rate was satisfactory.In addition,at 4℃,the storage time of the liquid skin test preparations of penicillin and streptomycin was 5 days and 179 days respectively.Conclusion:The spectropolarimetry can be adopted instead of the routine method to measure the content of penicillin and streptomycin in the liquid skin test preparations.

  • 【文献出处】 中日友好医院学报 ,Journal of China-japan Friendship Hospital , 编辑部邮箱 ,2001年02期
  • 【分类号】R927.11
  • 【被引频次】2
  • 【下载频次】61
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