【摘要】 目的　探讨术前应用免疫导向技术治疗胃癌的临床效果。方法　以应用 1 31 I -3H 11对 16例胃癌病人术前行内镜下癌灶多点注射作为治疗组 ;选择 6例胃癌病人采用FAM方案化疗作为对照组。并对术后标本进行观察。结果　术后病理检查治疗组发现 75 .0 %(12 16 )出现癌细胞核固缩、碎裂、细胞浆凝固、细胞间质出现炎性细胞浸润 ;这些变化多以中度为主 ,重度及无变化较少 ;而对照组无明显变化。结论　作为胃癌的综合治疗方法 ,术前胃癌局部注射1 31 I - 3H 11具有临床应用前景更多还原

【Abstract】 Objective To investigate the effect of intratumor injection of 131 I 3H11 for gastric cancer (GC). Methods 16 patients with GC subjected to endoscopic intratumor injection of 131 I 3H11 as a treatment group; 6 GC patients with FAM chemotherapy as a control group. Histological examination of the postoperative specimens of the two group were comparated. Results In treatment group, 75.0%(12/16) of cases were found to have morphological changes with karyopyknosis, karyorrhexis, coagulation of cytoplasm, and invasion of lymphocyte in mesochyma. Most of these changes were medial; but in control group no obvious morphological change was found. Conclusions The results suggest that GC subjected to endoscopic intratumor injection of 131 I 3H11 preoperatively has promising application in the clinic.更多还原