【摘要】 目的　探讨肝移植术后急性排斥反应的诊断与治疗。方法　对我院于 1999年 7月和 2 0 0 0年 4月为 2例肝豆状核变性患者施行背驮式同种异体原位肝移植术的临床资料进行回顾性分析。结果　术后常规给予环孢素A、硫唑嘌呤和甲基强的松龙三联免疫抑制剂。 2例肝移植术后共发生 5次急性排斥反应 ,经临床观察、肝功能化验结合肝穿活检 ,均得到了正确诊断。经大剂量肾上腺皮质激素、OKT3或FK5 0 6治疗后均被有效控制。结论　临床观察和肝功能化验可及时提示急性排斥反应的发生 ,诊断的最终确立依赖于肝穿活检 ,合理应用免疫抑制剂则是治疗的关键。更多还原

【Abstract】 Objective To investigate the diagnosis and treatment of acute rejection of orthotopic liver transplantation (OLT). Methods From July 1999 to April 2000, two piggyback liver transplantations were performed on two patients with Wilson’s disease. Results Cyclosporine A, azathioprine and methylprednisolone were the baseline immunosuppression management. Acute rejection occured 5 times in the 2 patients. The correct diagnosis was obtained through clinical inspection, liver function test and biopsy. The rejections were controlled by intensive steriod therapy plus OKT3 or FK506. Conclusions Clinical inspection and liver function test can suggest the episode of acute rejection in time. Hepatic biopsy is the key point for diagnosis of acute rejecton, Reasonable use of immunosppression is critical for the treatment.更多还原