【摘要】 目的 :观察人卵巢癌中CD1c、S 10 0阳性细胞数和表达强度的变化 ,探讨其与卵巢癌发生发展及预后的关系 ,为卵巢癌的生物治疗提供实验依据。方法 :应用ABC免疫组化技术和图像分析法对 31例卵巢癌标本进行检测。结果 :在卵巢癌中CD1c、S 10 0阳性细胞数与正常卵巢组织比较明显减少 (P <0 0 1) ,且其表达强与正常卵巢组织比较明显减弱 (P <0 0 1)。结论 :树突状细胞表型抗原在人卵巢癌组织中的表达总量下降 ,树突状细胞在抗卵巢癌的免疫反应中起重要作用。更多还原

【Abstract】 Objective:To investigate the numbers and distributions of dendritic cells and the expressive intensity of CD1c,S 100 in different human ovarian carcinoma tissues,and to discuss the relationship between them and the mechanism of development.The study can provide the experimental date of biological therapy of ovarian carcinoma.Methods:The samples of 31 patients with ovarian carcinoma were analyzed by ABC immunocytochemistry and computer imaging techniques.Results:The results showed that the number of positive dendritic cells in ovarian carcinoma reduced greatly with significant and the expressive intensity of CD1c,S 100 was weaker in ovarian carcinoma than in normal ovarian tissues.Conclusion:The total expression of dendritic cells phenotypic antigens was reduced in ovarian epithelial carcinoma,which may play an important role in initiating immunity against ovarian carcinoma.更多还原