【摘要】 目的 :研究 3种鼠 (小白鼠A、草原兔尾鼠B、子午沙鼠C)对戊肝病毒 (HEV)的反应。方法 :检查疫区捕获的小林姬鼠 ;对人工饲养繁殖后的B、C鼠实验感染HEV :第 1次用已证实含HEV·RNA的人粪便悬液攻击A、B、C 3种鼠 ;第 2次用已感染HEV的小林姬鼠和B鼠肝组织攻击 ,观察各种反应。结果 :第 1次攻击后临床表现少而轻 ,仅 2 0 %B鼠出现精神萎靡 ,A、B、C鼠全部有酶血症 ,C鼠排毒HCV·RNA+占 2 5 % ,肝组织普遍有病理反应 (占 30 %～ 10 0 % )。感染后死亡仅见B鼠 (占 5 0 % )。结论 :实验用 3种鼠均可感染HEV ,应重视其在传播中的作用 ,并可从中筛选动物模型目的 :研究 3种鼠 (小白鼠A、草原兔尾鼠B、子午沙鼠C)对戊肝病毒 (HEV)的反应。方法 :检查疫区捕获的小林姬鼠 ;对人工饲养繁殖后的B、C鼠实验感染HEV :第 1次用已证实含HEV·RNA的人粪便悬液攻击A、B、C 3种鼠 ;第 2次用已感染HEV的小林姬鼠和B鼠肝组织攻击 ,观察各种反应。结果 :第 1次攻击后临床表现少而轻 ,仅 2 0 %B鼠出现精神萎靡 ,A、B、C鼠全部有酶血症 ,C鼠排毒HCV·RNA+占 2 5 % ,肝组织普遍有病理反应 (占 30 %～ 10 0 % )。感染后死亡仅见B鼠 (占 5 0 % )。结论 :实验用 3种鼠均可感染HEV ,应重视其在传播中的作用 ,并可从中筛选动物模型更多还原

【Abstract】 Objective: Studying the reactions for HEV on mice(A), Lagurus lagurus (B),and Meriones meridianus (C). Methods:Check up Apodemus sylvaticus captured in HEV epidemic area,infect with HEV B and C bred in the laboratory.In the first time, animals A,B and C were injected by the suspension liquid of the dejecta of patient,who has been confirrmed to be infected HEVRNA.In the second time, the rodents were injected by the suspension liquid of the liver of Apodemus sylvaticus and B.It was observed for the clinical characters of all test animals. Result:The clinical characters of the rodents were light but only 20% of B was dispirited and inert and died to 50% after injected in the first time,there were special blood-enxyme characters in all animals.25% of C was found to be positive for HEVRNA.There was pathological reactions in liver tissues (from 30% to 100%). Conclusions: All three species can be infected by HEV,in which laboratory animal model for HEV can be sifted from the species. We must pay attention to their disease spreading function.更多还原