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脂肪酶改性对其在有机相中催化特性的影响

Lipase modification and its influence on lipase-catalyzed reaction rate and enantioselectivity in organic media

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【作者】 章亭洲; 杨立荣; 朱自强;

【Author】 ZHANG Ting zhou, YANG Li rong, ZHU Zi qiang(Dept. of Chem. Eng. & Bioeng, Zhejiang University , Hangzhou 310027,China)[WT5”HZ]

【机构】 浙江大学化学工程与生物工程学系!浙江杭州310027;

【摘要】 有机相酶催化近年来吸引了众多研究者的关注 .本文着重从酶的修饰 ,酶分子的生物印迹 ,酶晶体的交联 ,酶的纯化方式与预处理过程 ,酶的固定化等脂肪酶的改性因素对酶催化反应的速率与对映体选择性的影响作一综述

【Abstract】 WT5”BZ]Lipase catalyzed resolution and asymmetric synthesis in organic media have attracted many researchers in recent years. The reaction rate and enantioselectivity of these reactions are affected by many factors, including the modification of the enzyme, the imprinting of the enzyme, the cross linking of the enzyme, the purification and pretreatment procedure of the enzyme, and the immobilization method of the enzyme. This paper gives a review on these factors. These factors can greatly change the reaction rate and the enantioselectivity . [WT5”HZ]

【基金】 国家自然科学基金资助项目! (2 9876 0 37);浙江省自然科学基金资助项目!(2 96 0 6 8)
  • 【文献出处】 浙江大学学报(农业与生命科学版) ,Journal of Zhejiang Agricultural University(Agric.& Life Sci.) , 编辑部邮箱 ,2001年03期
  • 【分类号】TQ032
  • 【被引频次】30
  • 【下载频次】317
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