【摘要】 目的　探讨 5 -羟色胺 (5 - HT) 2 A受体基因 A- 1438G和 T10 2 C两种多态性与自杀未遂之间的关系。方法　以 149例自杀未遂者为研究对象 ,190名正常人为对照。采用聚合酶链反应 -限制性片段长度多态性 (polymerase chain reaction- restriction fragment length polymorphism,PCR- RFL P)方法 ,分析 5 -HT2 A受体基因 A- 1438G和 T10 2 C多态性。结果　 PCR- RFL P分析发现 ,男性自杀未遂与 5 - HT2 A受体基因 A- 1438G多态性的基因型 GG关联。结论　 5 - HT2 A受体基因 A- 1438G多态性可能与男性的自杀易感性相关。更多还原

【Abstract】 Objective To examine the relationship of attempted suicide with A 1438G and T102C polymorphisms of 5 HT2A receptor gene. Methods Genotypes and allele frequencies of A 1438G and T102C polymorphisms of 5 HT2A receptor gene in 149 attempted suicides and 190 normal controls were examined by polymerase chain reaction restriction fragment length polymorphism(PCR RFLP). Results No differences in genotypes and allele frequencies of A 1438G and T102C polymorphisms of 5 HT2A receptor gene were observed between attempted suicides and the controls. However, an association between male attempted suicides and genotype(GG) of A 1438G polymorphism was found. Conclusion These results suggested that liability to suicide behavior might be associated with A 1438G polymorpyhism of 5 HT2A receptor gene in male subjects.更多还原