【摘要】 目的　种族间血脂水平的差异已有研究。本文拟探讨民族间血脂、脂蛋白及载脂蛋白水平是否也存在差异。方法　作者对新疆地区的汉族居民 911人 (男性 4 6 6人 ,女性 4 45人 )及哈萨克族居民 773人 (男性 36 0人 ,女性4 13人 )随机个体血总胆固醇 (TC)、甘油三酯 (TG)、高密度脂蛋白胆固醇 (HDL c)、低密度脂蛋白胆固醇 (LDL c)、脂蛋白 (a) (Lp(a) )及载脂蛋白A1(ApoA1)、载脂蛋白B(ApoB)进行测定。结果　与汉族人群比较 ,哈萨克族人群男、女均分别有较高的HDL c(P <0 0 0 1)和ApoA1(P <0 0 0 1)水平与较低的TG(P <0 0 1,P <0 0 0 1)、Lp(a) (P <0 0 0 5 )、ApoB(P <0 0 0 5 ,P <0 0 0 1)及较低的ApoB/ApoA1值 (P <0 0 1,P<0 0 0 1) ;汉族人群有 2 0 7%的个体ApoA1水平值低于 1 2g/L ,而在哈萨克族人群中只有 9 8%的个体ApoA1值低于 1 2g/L ,汉族人群有 18 6 %的个值ApoB值高于 1 2g/L ,而在哈萨克族人群中只有 14 3%的个体ApoB水平值超过 1 2g/L ;多因素相关与回归分析发现 :TG、HDL c、Lp(a)、ApoAI及ApoB/ApoAI值水平均与民族有密切的相关关系。结论　血脂、Lp(a)、ApoA1及ApoB水平存在显著的民族间的差异 ,哈萨克族人群具有较汉族人群明显为优的血脂谱 ,推测遗传因素可能控制和影响着个体更多还原

【Abstract】 Objective To reveal the distribution characteristics of serum lipids, lipoproteins,and apolipoproteins levels in different nationalities、 Methods Quantitative levels of those traits mentioned above were determined and body height (H), weight (W) and body mass index (BMI=W/H 2) were assessed in 773 Kazaks (men 360 and women 413) and 911 Han nationality (men 466 and women 445) from the Xinjiang Autonomous Region of China、 Results Kazaks men and women, respectively, had significantly higher serum levels of HDL-c and ApoA1 (all P<0、001) and significantly lower serum levels of TG (men P<0、01, women P<0、001), Lp(a) (all P<0、005), ApoB (men P<0、005, women P<0、001) and ApoB/A1 (men P<0、01, women P<0、001) than their Han nationality controls、 The threshold points of ApoA1 (<1、2?g/L) and ApoB (>1、2?g/L) are higher in Hans than in Kazaks for ApoA1 (20、7 vs 9、8%) and ApoB (18、6 vs 14、3%); the serum levels of TG, HDL-c, Lp(a), ApoA1 and ApoB/A1 are all closely correlated with nationality (P<0、001, P=0、001, and P<0、05, respectively)、 Conclusion The results suggest that the nationality differences exist in serum levels of lipids, lipoproteins, and apolipoproteins, and Kazaks have a superior serum lipid pedigree to Hans、 This differences may come from genetic differences, which affect the serum levels of lipids, lipoproteins,and apolipoproteins by controlling lipid metabolism patterns、 Future study will be needed to dissect to the role of genetic factors on serum lipids更多还原