【摘要】 目的　观察干扰素 (IFNα 2b)联合胸腺肽治疗慢性乙型肝炎临床疗效。方法　干扰素5 0 0万IU ,皮下注射 ,隔日 1次 ,疗程 6个月。胸腺肽 2 0mg稀释后静脉注射或肌注 ,隔日 1次 ,疗程 3个月。以甘利欣 ,五味子制剂及垂盆草冲剂作对照 ,二者在性别、年龄、病程及病情轻重等方面皆具可比性。结果　HBVDNA和HBeAg的阴转率及总有效率分别为 75 % ,73 1% ,与对照组相比差异显著(P <0 0 1) ,在肝功能复常方面 ,治疗组与对照组相似。结论　干扰素对乙型肝炎病毒有明显抑制作用 ,尤其是HBVDNA和HBeAg同时阳性者 ,呈完全应答。更多还原

【Abstract】 Objective To determine the effects of IFN\|α 2b associated with thymus peptides in treatment of chronic hepatitis B. Methods A total of 52 individuls with chronic hepatitis B received IFN\|α 2b(5×10 6IU/ml qod)for 6 months and thymus peptides(20mg qod) for 3 months.50 patients received SMMC or other medicine such as WuWeizi,CuiPenCao served as control.There were no differences between two groups in sex,age,duration and seriousness of the disease. Results The primary outcome measure for efficacy was the percentage of HBV DNA/HBeAg negativity after 6 months’ therapy.Rate of HBV DNA negativity was 75% and that of HBeAg was 73.1%,the inhibitory activity of IFN\|α 2b against HBV was significantly higher than that of the control.Except transient fever,leukopenia and thrombocytopenia appearing at the beginning of the herapy,no serious adverse events were observed. Conclusion Potent inhibitory activity against HBV of IFN\|α 2b is suggested and much works need to be done to improve the long\|term effect of the therapy.更多还原