【摘要】 对叶绿素 a降解产物紫红素 - 18(1)在非细胞体系中的光敏化力和对小鼠肉瘤 - 180的光动力治疗作用进行了研究。结果表明 ,1在 D2 O中对 NADPH的光氧化作用的敏化效应明显高于参比药物血卟啉衍生物 (Hp D) ;其 4mg/ kg时肿瘤抑制率可达 95 .1% ,疗效较 Hp D显著 (P<0 .0 1更多还原

【Abstract】 The sensitizing effect of purpurin 18 on photooxidation of NADPH in deuterium oxide and its photodynamic effect on sarcoma 180 in mice in different doses and at different intervals between injection and irradiation were investigated. It was found that the photosensitizing effect of purpurin 18 was much higher than that of the reference drug hematoporphyrin derivative (HpD). The tumor inhibition rate of purpurin 18 at the dose of 4 mg/kg was 95.1%, significantly different from HpD ( P <0.01).更多还原