【摘要】 目的　探讨癌基因c erbB 2和肿瘤转移抑制基因nm2 3H1的产物在胆囊癌组织中的表达与其生物学意义。方法　采用免疫组织化学方法检测胆囊癌标本中c erbB 2和nm2 3H1蛋白的表达 ,分析其与临床病理间关系。结果　c erbB 2和nm2 3H1蛋白的阳性表达率分别为 43 75 % (2 8/ 6 4)和 5 4 6 9% (35 / 6 4)。Ⅳ期胆囊癌中c erbB 2蛋白阳性率 (80 % )明显高于其他期胆囊癌 (P <0 0 1) ,c erbB 2阳性组平均生存期差于阴性组 (P <0 0 5 )。而nm2 3H1蛋白的表达与肿瘤的分化、分期和预后无关。结论　在胆囊癌中 ,c erbB 2和nm2 3H1参与肿瘤发生发展过程 ,c erbB 2的表达与肿瘤的转移和预后有着密切关系。更多还原

【Abstract】 Objective To detect the expression of oncoprotein c erbB 2 and nm23H 1 in gallbladder carcinoma and explore its biological significance. Methods The expression of c erbB 2 and nm23H 1 in gallbladder carcinoma was detected with immunohistochemistry. Meanwhile, the relationship between the expression and clinical pathology of the tumor was analyzed. Results The positive rates of the expression of oncoprotein c erbB 2 and nm23H 1 were 43.75% and 54.69%, respectively. The positivity of c erbB 2 protein was significantly higher in gallbladder carcinoma at stage Ⅱ than in that at other stages (P<0.01). The survival time of c erbB 2 positive group was markedly lower than that of the negative one (P<0.05). However, the expression of nm23H 1 was not related to the tumor differentiation, staging and prognosis. Conclusions The protooncogene c erbB 2 and anti metastatic gene nm23H 1 participate in the oncogenesis and development of gallbladder carcinoma and the expression of c erbB 2 is related to the metastasis and prognosis of the tumor.更多还原