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滇白珠提取物抗细菌活性的筛选

Screening of Anti-bacteria Activity of Extracts of Gaultheria leucocarpa var. yunnanensis

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【作者】 马小军; 赵玲; 杜程芳; 宫毓静; 郑俊华; 陈新滋;

【Author】 MA Xiao-jun 1,ZHAO Ling,DU Cheng-fang 1, Gong Yu-jing1, ZHENG Jun-hua 1,CHEN Xin-zi 2 (1.Department of Natural Medicines, School of Pharmaceutical Science, Beijing University,Beijing 100083,China; 2.Department of Applied Biology and Chemical Tech

【机构】 北京大学药学院天然药物学系!北京100083; 北京职工医学院!2000届实习生; 香港理工大学应用生物及化学科技学系;

【摘要】 目的 :筛选滇白珠抗菌成分 ,为更全面的评价和开发滇白珠提供依据。方法 :成分提取用萃取、层析等常规方法。抗菌力测定用纸片扩散法。结果和结论 :在滇白珠不同部位、不同极性的 2 2个提取物中有 3个提取物有较显著的抑制金黄色葡萄球菌作用 ,且根与茎的提取物作用一致 ;2个提取物有一定的抑制大肠杆菌和绿脓杆菌作用 ,说明滇白珠根水提物、乙酸乙酯和正丁醇萃取物均有一定的抑菌作用。首次证明滇白珠非挥发部分也有抗细菌作用。

【Abstract】 Objective:To further develop Gaultheria leucocarpa var. yunnanensis,anti-bacteria constituents in it were screeened. Method:The constituents were extracted by chromatographic process.The anti-bacteria test was made with regulatory method of analysis. Result and conclusion: Anti-bacteria test with extracts of water, acetic ester and n-butanol showed that 3 extracts from 22 samples had anti-Staphylococcus aureus action, and the extracts from root and stem showed the same result. 2 extracts could kill Escherichia coli and Pseudomonas aeruginosa. The lower the concentrate, the less the anti-bacteria action was. These results suggested that not only essential oil but other ingredients from G.leucocarpa var. yunnanensis have anti-bacteria activity . Anti-fungi test of the same extracts didn’t indicate remarkable action.\

  • 【文献出处】 中国中药杂志 ,China Journal of Chinese Materia Medica , 编辑部邮箱 ,2001年04期
  • 【分类号】R285.5
  • 【被引频次】21
  • 【下载频次】319
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