【摘要】 目的　研究精氨酸 (Arg)对大肠癌患者免疫功能的影响。方法　大肠癌患者 34例 ,随机分为实验组、对照组。实验组每日静脉输注Arg2 5克、连续三天。检测外周血细胞免疫指标 [T细胞亚群 (CD+3、CD+4、CD+8)、NK细胞活性、淋巴细胞转化率 ]、红细胞免疫指标 [红细胞C3b受体花环率 (C3bRR)、红细胞免疫复合物花环率 (ICR)、循环免疫复合物 (CIC) ]、体液免疫指标 (免疫球蛋白和补体 )的变化。结果　实验组CD+4、CD+4/CD+8、NK细胞活性、C3bRR均有提高 ,有统计学意义 ,尤以CD+4、NK细胞活性提高明显 (P <0 .0 1) ;淋巴细胞转化率和CIC亦有改善 ,但仅组内比较有差异 (P<0 .0 5 ) ;ICR降低 ,但无统计学意义 (P >0 .0 5 ) ;C3bRR变化与NK细胞活性变化之间呈正相关 (r =0 .5 80 4,P <0 .0 5 ) ,而对照组各指标均无显著变化 (P >0 .0 5 ) ;体液免疫指标无显著变化 (P >0 .0 5 )。结论　短期应用药理剂量的Arg可以改善大肠癌患者的细胞免疫、红细胞免疫功能。更多还原

【Abstract】 Objective In order to study the effect of L-arginine on the immune function in patients with colorectal cancer.Methods 34 patients with colorectal cancer were randomly divided into experimental group,in which patients received hydrochloride arginine 25 gram/day for three days,and control group.The changes of peripheral blood cellular immune parameters such as T lymphocyte subsets,lymphocyte transformation rate (LTR) and natural killer(NK) cell activity,red blood cell (RBC) immune parameters as C 3b RR,ICR and circulating immune compound(CIC) were determined,and at the same time,humoral immune parameters were also determined.Results In experimental group,there were significant improvement on CD + 4,CD + 4/CD + 8,NK cell activity,C 3b RR, especially CD + 4 and NK cell activity(P<0.01).ICR decreased without statistical significance(P>0.05).There was positive correlation between the change of C 3b RR and that of NK cell activity(r=0.5804,P<0.05).Conclusion The short term application of L-arginine in pharmaceutical dosage could improve cellular and RBC immunity.更多还原