【摘要】 目的　比较国产微晶纤维素和日本旭化成Avicel几种型号微晶纤维素作为片剂辅料的各项性能。方法　测定并比较各种微晶纤维素的粒径、流动性、溶胀性、崩解性等性能 ,并以马来酸氯苯那敏为模型药物 ,湿法制粒压片 ,考察片剂的崩解度。结果　国产微晶纤维素的一些性能比Avicel差。但湿法制粒时 ,其崩解作用优于AvicelPH10 1。结论　国产微晶纤维素不宜用于粉末直接压片 ,但能够应用于湿法制粒更多还原

【Abstract】 OBJECTIVE The properties as tablet excipient of domestic microcrystatin cellulose(MCC) and Japan Avicel were investigated.METHODS The granularity ,fluidity ,swelling capacity and disintegration of MCC were determined and compared.The chlorphenamini maleas tablet was prepared by wetting-granule method and its disintegration was determined.RESULTS Some properties of domestic MCC were inferior to Avicel’s. The disintegration of domestic MCC that was applied to wetting-granule method was superior to Avicel’s.CONCLUSION The domestic MCC can not be applied to direct compression method but can be applied to wetting-granule method.更多还原