【摘要】 目的 :探讨约氏疟原虫感染早期一氧化氮 (nitricoxide ,NO)对红内期疟原虫的影响。方法 :通过ELISA和Griess反应 ,观察疟原虫感染早期宿主体内细胞因子和NO对红内期虫体血症的影响及其效应。结果 :疟原虫感染早期随着以IFN γ分泌增加为主的Th1细胞免疫应答产生的过程 ,NO合成逐渐增加 ,红内期原虫血症受到抑制。一旦解除高水平NO的作用 ,虫体的增殖能力即可迅速得以恢复。结论 :NO通过抑制裂殖子的侵袭力发挥抗红内期原虫感染的保护性免疫效应。更多还原

【Abstract】 Objective: Our purpose was to observe the effects of nitric oxide(NO) on blood-stage malaria during the early phase of plasmodium yoelii infection.Methods:By using ELISA and Griess reaction, we investigated the effects of cytokines and NO on parasitemia during the early phase of infection.Results:Increased NO production induced by IFN-γ inhibited parasitemia. Once NO effect was removed, the proliferation ability of parasites could recover rapidly.Conclusion:The NO has protective role against blood-stage malaria by inhibiting schizont infectivity during the early phase of plasmodium yoelii infection.更多还原