【摘要】 目的　应用PTC针脐带穿刺取胎儿血进行产前诊断 ,评价其安全性及准确性 ,探索穿刺技巧。方法　用PTC穿刺针在超声引导下对 49例经遗传咨询筛选符合宫内诊断指征者进行了 5 1次脐带穿刺术。结果　穿刺成功率 94 1% (4 8/ 5 1) ,最终取血成功率为 98 0 % (4 8/ 49)。发现染色体平衡易位 3例 ,2 1三体 1例 ,甲型血友病 1例 ,宫内CMV感染伴胎儿异常 1例 ,亲子鉴定非丈夫血缘 1例。结论　使用PTC穿刺针进行脐带穿刺有较高的准确性及成功率 ,是较为有效的产前诊断方法更多还原

【Abstract】 Objective\ To carry out intrauterine diagnosis by fetal blood sampling through cordocentensis by PTC needle,to evaluate its security and accuracy and research the skill of cordocentensis.Methods\ We carried out 51 cordocentensis by PTC needle under ultrasound-guide in 49 cases.These cases conformed to the indications of intrauterine diagnosis after genetic counsel screening.Results\ The successful rate of puncture was 94 1%(48/51),the final successful rate of fetal blood sampling was 98 0%(48/49).There were 3 cases with chromosome balanced translocations,1 with trisomy 21,1 with hemophilia A 1 with intrauterine CMV infection and abnormal fetus and 1 case with non-husband-consanguinity by identification in disputed paternity.Conclusion\ Cordocentensis by PTC needle is more accurate and successful,this technique is an effective method in prenatal diagnosis.更多还原