【摘要】 目的　研究青光眼对视网膜脉络膜血液循环的影响。方法　选 2 4月龄、体重 3 5～ 4kg的先天性青光眼大耳白兔 5只 (7只眼 ) ,选 1 0只同龄大耳白兔作为对照组。另选 1 0只 2月龄、体重 2kg大耳白兔前房内灌注生理盐水制成急性高眼压模型。对三组兔进行眼底照像、闪光视诱发电位 (FVEP)检查 ,观察视网膜脉络膜血管形态和FVEP的变化。对人工急性高眼压组还进行了闪光视网膜电流图 (FERG)检查。结果　先天性青光眼组与同龄对照组相比视网膜脉络膜末梢血管网明显减少 ;人工急性高眼压组眼压升高后首先使视网膜脉络膜末梢血管网灌流不足 ,随着眼压的继续升高脉络膜大血管变细 ,末梢血管网灌流不足加重 ,眼压极度升高时脉络膜大血管血流中断。同龄正常对照组的FVEP的主波P10 0 潜伏期是 (83± 9)ms,先天性青光眼组则为 (1 1 2± 1 4)ms,差异有非常显著意义(P <0 0 1 ) ;人工急性高眼压组高眼压前为 (69± 5)ms,眼压 60～ 80mmHg时延长为 (81± 7)ms,眼压在 1 0 0～ 1 30mmHg时FVEP波形低平 ,近似直线 ;眼压恢复正常后 2hFVEP的P10 0 潜伏期为 (82± 8)ms。人工急性高眼压前后FERG变化显著。结论　青光眼可以影响视网膜脉络膜血液循环 ;可使FVEP、FERG发生变化更多还原

【Abstract】 Objective To investigate the effect of glaucoma on rabbit retinal and choroidal circulation Methods Congenital glaucoma group was composed of 5rabbits(7 eyes) of 24 months old,weighed 3 5-4kg; control group: 10 rabbits with the same age; animal model group: 10 rabbits of 2 months old, weighted 2kg, its hypertension developed by perfusing the anterior chamber with normal saline Through the fundus photos and flash visual evoked potential (FVEP), we observed the shapes ofretinal and choroidal blood vessels, and the changes of FVEP Flash electroretinogram (FERG) was used in the man-made acute hypertension rabbits Results Compared with the control group, the retinal and choroidal vessel endings of congenital glaucoma rabbits were obviously decreased In man-made acute hypertension rabbits, acute elevation of intraocular pressure (IOP) firstly caused the ischemia of retinal and choroidal vessel endings, with the large blood vessels thinned, even the blood flow discontinued FVEP P 100 latent period: control (83±9) ms, congenital glaucoma (112±14) ms, the difference was significant (p<0 01) ; man-made acute hypertension: (69±5) ms before the elevation of IOP, (81±7) ms at 60-80mmHg, the wave was similar to a line at 100-130mmHg, (82±8)ms at 2 hours after IOP was restored to normal FERG changed abruptly before and after the hypertention Conclusion Glaucoma may effect the retinal and choroidal circulation, and cause the changes of FVEP and FERG更多还原