【摘要】 目的 :研究E cadherin、nm2 3在甲状腺乳头状腺癌 (papillarythyroidcarcinoma ,PTC)中的表达及其临床意义。方法 :应用免疫组化SP法 ,检测 70例PTC中E cadherin、nm2 3的表达。结果 :E cadherin、nm2 3的阳性表达率分别为 44 .3% (31 70 ) ,6 2 .9% (4 4 70 ) ,分别与PTC的病理分级、TNM分期及淋巴结转移有关 (P <0 .0 5 ) ,而与患者性别、年龄及肿瘤大小无明显的关系 (P >0 .0 5 ) ;E cadherin、nm2 3的表达具有高度的协同性 ;两者同时阳性表达的PTC ,其淋巴结转移率为 12 % (3 2 5 ) ,同时阴性表达的 ,其淋巴结转移率为 75 % (15 2 0 ) ,两组之间有显著性差异 (P<0 .0 0 1)。结论 :E cadherin、nm2 3在PTC浸润和转移方面存在相关性 ,可作为预测PTC生物学行为的标志更多还原

【Abstract】 Purpose:To investigate the expression of E cadherin and nm23 in papillary thyroid carcinoma (PTC) and its clinical significance. Methods:The expression of E cadherin and nm23 were detected by SP immunohistochemical technique in 70 paraffin embedded tissue specimens of PTC.Results:The positive rates of E cadherin and nm23 were 44.3%(31/70) and 62.9%(44/70) respectively. There were close relations between the expression of E cadherin and nm23 and pathological grade, TNM stage and lymph node metastasis, and no difference could be found between the expression of E cadherin and nm23 and size of tumor, sex and age of patients. There was distinct correlation between the expression of E cadherin and nm23. The metastatic rate in the group, which the expression of E cadherin and nm23 were both positive, was 12%(3/25), but in the all negative group, the metastatic rate was 75%(15/20). There was significant difference between the two groups ( P <0.001). Conclusions:E cadherin and nm23 might play important roles in invasion and metastasis of PTC, and might be useful markers for evaluating the biological behavior of PTC. [更多还原