【摘要】 目的 :尽管我国胃癌死亡率有下降趋势 ,但仍旧是第二位恶性肿瘤 ,扬中是我国胃癌高发区之一。我们在扬中进行胃癌和慢性胃炎与饮绿茶的调查 ,以研究饮绿茶与它们发病的关系。以及他们之间的交互作用。方法 :在扬中开展以人群基础的病例对照调查 :其中有病理学证明的胃癌 143例 ,慢性胃炎 16 6例和对照 433例。用统一的流行病学调查表 ,同时采血作幽门螺杆菌感染测定。分析用logistic回归计算比数比 (OR)和 95 %可信限(CI)。分析时用各种混杂因素进行调整。结果 :饮绿茶可降低胃癌和慢性胃炎危险度各 5 4% ,其比数比分别为 :0 46 (95 %CI:0 2 2— 0 96 )和 0 46 (95 %CI :0 2 7— 0 77)。每周饮绿茶杯数愈多 ,胃癌和慢性胃炎OR下降愈低 (趋势检验P <0 .0 5 )。饮绿茶与胃癌家族史 ,幽门螺杆菌感染和饮酒可能有相乘交互作用。结论 :饮绿茶可降低胃癌和慢性胃炎危险度各 5 4%。更多还原

【Abstract】 Purpose:Despite the declining trend of stomach cancer incidence, it is still the second important cancer in China and ranks first in Yangzhong City. We examined the role of green tea consumption on stomach cancer and chronic gastritis risks by case control study. Interaction between green tea drinking and potential risk factors of stomach cancer and chronic gastrotitis were also explored. Methods:A population based case control study was conducted in Yangzhong, China, with 143 stomach cancer patients, 166 chronic gastitis patients and 433 healthy controls. Epidemiological data were collected by standard questionnaire, and blood samples were obtained for measurement of Helicobacter pylori infection. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using logistic regression models. Results:Inverse association was observed between green tea drinking and stomach cancer and chronic gastritis risks. After adjusting for potential confounding factors, ORs of green tea drinking were 0.46 (95%CI: 0.22—0.96) and 0,46 (95%CI: 0.27—0.77) for stomach cancer and chronic gastritis, respectively. The less ORs of stomach cancer and chronic gastritis, the more frequent the green tea drinking ( P for trend <0.05). Possible interaction was observed between green tea and H. pylori infection as well as alcohol drinking.Conclusions:Green tea drinking will decrease by 54% the risk for both stomach cancer and chronic gastritis.更多还原