【摘要】 目的　分析和评价住院肺结核病人的耐药动态 ,为今后的结防工作提供参考依据。方法　收集本院不同年代 (1982～ 1983,1990～ 1991和 1997～ 1998年 )住院病例 ,进行耐药率的分析。结果　原发耐药率分别为 2 4 .6 % ,35.1%和 38.3% ,原发耐多药率分别为 3.5% ,6 .1%和 12 .3%。获得性耐药率分别为 81.0 % ,6 5.8%和 74 .4 % ;获得性耐多药率分别为 11.5% ,16 .6 %和 34.9%。原发耐药率、原发和获得耐多药率有逐年增长的趋势 ,获得性耐药率变化不大。结论　控制耐药的关键是实施NTP ,统一化疗方案 ,广泛实施DOTS ,做好耐药监测评价工作。更多还原

【Abstract】 Objective To analyse and evaluate the trend of antituberculosis drugs resistance for in-patient pulmonary tuberculosis for a better job of tuberculosis control.Methods To collect in-patient cases in different years, i.e.1980～1981,1990～1991,1997～1998.The trend of drug resistance was analysed.Results The prevalence of primary drug resistance was 24.6%,35.1% and 38.3% respectively in three periods.The prevalence of primary MDR-TB drug resistance was 3.5%,6.1% and 12.3% respectively.The prevalence of acquired drug resistance was 81.0%,65.8% and 74.4% respectively.The prevalence of acquired MDR-TB drug resistance was 11.5%,16.6% and 34.9% respectively.The perevalence of primary and acquired MDR-TB drug resistance was increasing but the prevalance of acquired drug resistance was almost steadily decreasing.Conclusion The key of controlling drug resistance is to implement NTP,to standardize chemotherapy regimens,to implement DOTS,and to improve the evaluation work of drug resistance.更多还原