【摘要】 目的　为了弄清蒿甲醚合成母液中的衍生杂质结构及开发新的药源。方法　用色谱法从合成蒿甲醚的母液中分离其衍生物成分 ,并用化学波谱法鉴定其结构。　结果　分离得到 5个化合物分别鉴定为α-蒿甲醚 ( ) ,二氢青蒿素 ( ) ,青蒿素 ( ) ,八氢 - 8-甲氧基 - 4,7-二甲基 -呋喃 [3,2 - i]苯并吡喃 - 10 -乙酸酯 ( )和 12 -脱氧 - 11-烯青蒿素 ( )。结论　化合物 为一新化合物 ,命名为 12 -脱氧 - 11-烯青蒿素 ,并首次从合成蒿甲醚的母液中得到。更多还原

【Abstract】 Object To isolate and identify the artemisinin like impurities present in the mother liquor of synthetic dihydro artemisinin methyl ether, for the development of new drugs Methods Artemisinin like compounds in the synthetic mother liquor were isolated by chromatography Results 5 compounds were isolated and identified They were α dihydroartemisinin methyl ether (Ⅰ); α, 12 deoxy artemisinin 12 ol (Ⅱ); artemisinin (Ⅲ); octahydro 8 methoxy 4, 7 dimethyl furo benzopyran 10 yl acetate (Ⅳ) and 12 deoxy 11 en artemisinin (Ⅴ) Conclusion Compound Ⅴ was new更多还原