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青霉素V钾分散片的研制
Research of phenoxymethylpenicillin potassium dispersible tablets
【摘要】 目的:筛选青霉素V钾分散片的处方.建立青霉素V钾分散片的含量测定方法。方法:采用均匀设计法筛选处方;紫外分析法测定含量。结果:青霉素 V钾分散片崩解时限45~90s,T50 1.09min,Td 2.07min;紫外测定回收率97.54%。结论:按本文处方生产的青霉素V钾分散片质量符合英国药典对分散片的要求;紫外方法快速、简便,准确度较高。
【Abstract】 OBJECTIVE: To optimize prescriptions of phenoxymethylpenicillin potassium (VK) dispersible tab- lets and establishe content measuring method. METHODS: Uniform design method and UV method were used. RE- SULTS:The results were as follows: breaking time 45 ~ 90s, T50 1. 09min, Td 2. 07min, recovery ratio 97. 54%. CONCLUSION:The quality of phenoxymethylpeniniclillin potassium dispersible tablets is conform to Britain Phar-macopoeia and UV method is simple and rapid.
【关键词】 青霉素V钾;
分散片;
均匀设计;
【Key words】 phenoxymethylpenicillin potassium; dispersible tablets; uniform design;
【Key words】 phenoxymethylpenicillin potassium; dispersible tablets; uniform design;
- 【文献出处】 药学实践杂志 ,The Journal of Pharmaceutical Practice , 编辑部邮箱 ,2001年05期
- 【分类号】R944.4
- 【下载频次】109