【摘要】 松口蘑菌丝体水提液中活性糖蛋白MTSGS1在体外抗肿瘤试验中具有直接杀伤肿瘤细胞的作用 ,较低剂量 (2 0～ 16 0 μg/ml)时即能抑制HeLa细胞增殖 ,诱导细胞形态异常 ,细胞发生调亡。MTSGS1是通过抑制细胞周期中S到G2M期的转化阶段抑制HeLa细胞增殖 ,诱导细胞发生调亡的。MTSGS1动物体内抗肿瘤实验具有显著的抑癌作用 ,在 5 0mg/ (kg .d)时抑癌率达 6 5 % ,脾重及脾指数显著增高。体内外抗肿瘤实验表明具有较好的抑癌活性更多还原

【Abstract】 The active glycoprotein MTSGS1 from the mycelium of T. matsutake has antitumor activity in vitro . Low dose of MTSGS1 can inhibit cell proliferation and induced cell apoptosis by inhibiting cell conversion from S to G2M state. MTSGS1 inhibits S 180 cell multiplication in vivo , the antitumor ratio is 65% at 50mg/(kg.d). The spleen weight and index increase markedly. The results show that MTSGS1 has obvious antitumor activity in vitro and in vivo.更多还原