【摘要】 Cbfα1基因编码一个成骨细胞特异性转录因子 ,调控成骨细胞发育、分化和骨的形成。Cbfα1基因含 9个外显子 ,但它的多个外显子存在选择性剪接 ,产生多样Cbfα1的异构体 ,具有不同的转录激活潜能。多条信号传导通路如Ras MAPK、cAMP、Smads DPC4通路等涉及到Cbfα1的活性或表达的调控。这些研究为药物调控成骨细胞分化和骨的形成及基因治疗骨质疏松症开拓新的思路更多还原

【Abstract】 Cbfα1 gene encodes an osteoblast specific transcription factor that regulates osteoblast differentiation and bone formation. The Cbfα1 gene contains 9 exons, however, the alternative splicing of its exons leads to genesis of multiple Cbfα1 isoforms with differences in transactivation potentials. Several signal transduction pathways, such as Ras MAPK pathway, cAMP pathway, or Smads DPC4 pathway, are involved in regulating Cbfα1 activity or its expression. These studies open new doors in pharmacological control of bone formation and gene or cell therapy of slowing the progression of osteoporosis.更多还原