【摘要】 采用细胞色素c法研究了水杨酸铜分别在中性、正负电性脂质体中SOD样活性的变化情况。证明中性脂质体包裹的水杨酸铜的SOD样活性比水杨酸铜在水溶液中提高了3倍多。但正负电性脂质体包裹的水杨酸铜的SOD样活性降低。并发现在实验浓度范围内，负电性脂质体包裹的水杨酸铜，活性变化无规则，且荷负电量多的脂质体包裹的水杨酸铜促进超氧自由基的歧化，而荷负电量少的脂质体仅在低浓度区对超氧的歧化表现为促进作用。更多还原

【Abstract】 The SOD-like activities of copper salicylate encapsulated in neutral, positively and negatively charged liposomes were studied with cytochrome c method. The results showed that the SOD-like activity of copper salicylate encapsulated in neutral liposomes was enhanced over 3 times more than that of copper salicylate in aqueous solution. However, the activity decreased for copper salicylate encapsulated in positively and negatively charged liposomes. It was also found that at experimental concentrations there was no regularity for the change of activity of copper salicylate encapsulated in negatively charged liposomes, and copper salicylate encapsulated in liposomes with more negative charges could promote the dismutation of superoxide anion free radicals, however, so could copper salicylate encapsulated in liposomes with fewer negative charges only in lower concentrations.更多还原