【摘要】 目的　探讨P53 及c -myc蛋白在食管癌及癌前病变中的表达及意义。方法　应用免疫组化SP法检测P53 及c -myc在 6 0例食管癌及 33例非典型增生中的表达。 结果　P53 及c -myc蛋白分别在食管癌与非典型增生I～II级中表达有显著差异 (P <0 .0 5 ) ;在食管癌与非典型增生III级表达中无显著差异 (P >0 .0 5 )。结论　P53 及c -myc蛋白异常表达 ,可为食管癌和癌前病变界限的划分提供参考依据。更多还原

【Abstract】 Objective To investigate the significance of P 53 and c-myc protein expression in precancerous lesions and cancers of esophagus. Method TheP 53 and c-myc protein expression were determined by using SP immunohistochemistry staining method. Result Significant differences were detected between esophageal cancer group and each dysplasia group (P<0.05) in both P 53 and c-myc oncoprotein expression, except for dysplasia grade Ⅲ (P>0.05). Conclusion The abnormal expression of P 53 and c-myc protein may offer a reference for the grading and classification of esophageal carcinoma and precancer lesions.更多还原