【摘要】 目的:探讨各种肝病患者血浆内皮素 - 1(ET- 1)水平的临床意义。方法:用放射免疫法检测急、慢性肝炎、重症肝炎、肝硬化和肝癌患者血清 ET- 1的含量。 结果 :血浆 ET- 1水平在急性肝炎为 (87.3± 41.5 ) pg/ ml,慢性肝炎组为 (115 .4± 48.6 ) pg/ ml,重症肝炎组为 (6 3.4± 40 .4) pg/ ml,肝硬化组为 (78.8± 45 .0 ) pg/ ml,肝癌患者血为 (81.5± 46 .0 ) pg/ m l,均明显高于对照组 (34 .32± 19.38) pg/ m l,P均 <0 .0 1。 结论:血浆 ET- 1水平升高在各型肝病发生以及肝病的病理、生理改变过程有重要的作用。更多还原

【Abstract】 Objective: Study of the significance of serum edothin-1(ET-1) in the patients with various hepatic diseases. Methods: The value of serum ET-1 in 113 patients(21 cases in acute hepatitis, 55 in chronic hepatitis, 22 in sever type hepatitis, 11 in liver cirrhosis, and 4 in hepatocelular carcinoma) were detected with radioimmunoarray(RIA). Results: The detected results showed that the serum level of endothin-1, comparing with that in control group(34.3±19.4 pg/ml), was significantly different in acute hepatitis(87.3±41.5 pg/ml), chronic hepatitis(115.4±48.6 pg/ml), sever type hepatitis(63.4±40.4 pg/ml), liver cirrhosis(78.8±45.0 pg/ml), and hepatocellular carcinoma(81.5±46.0 pg/ml)in statistics(P< 0.01). Conclusion: serum endothin-1 has important role in the course of various liver diseases and in the process of change of their pathophysiology.更多还原