【摘要】 [目的]探讨Ⅰ期子宫内膜腺癌患者的预后因素。[方法]通过86例Ⅰ期子宫内膜腺癌患者的治疗随访 ,对年龄、细胞分化、肌层浸润、脉管癌栓、受体、手术方式、C erbB₂、p53等因素及生存率进行COX模型统计分析。[结果]总5年生存率为90.7 %。单因素分析结果细胞分化、肌层浸润、受体、C erbB₂、p53与预后有关。但多因素分析仅细胞分化、肌层浸润、PR为独立的预后因素。[结论]子宫内膜癌细胞分化低、肌层浸润深患者预后差 ,治疗时需足够重视 ;而PR阳性可能是子宫内膜癌患者的保护因素更多还原

【Abstract】 To investigate prognostic factors in patients with stage Ⅰ endometrial carcinoma.The age,histologic grade,lymphovascular invasion,myometrial invasion,surgery,ER,PR,C erbB₂,p53 were analysed retrospectively with COX models in 86 patients with stage Ⅰ endometrial carcinoma.The overall 5 year survival was 90.7%.There were statistically significant correlations between differential grade,myometrial invasion,ER,PR,C erbB₂,p53 by single factor analysis,while only grade,myometriam invasion,PR had independent prognostic significance by mutiple_factor analysis.[Conclusion]The patients with stage Ⅰ endometrial carcinoma of high grade and deep myometrial invasion had poor prognoses and PR may be an independent protective factor.更多还原