【摘要】 [目的]观察羟基喜树碱联合ELF方案治疗晚期胃癌的疗效和毒副作用。[方法]42例晚期胃癌患者接受羟基喜树碱40mg静滴d1,d5,CF200mg/m2 ,静滴d1～5,CF后接着用5 Fu500mg/m2静滴d1～5,Vp1680mg/m2静滴d1～5,21天为一周期。[结果]可评价疗效患者36例 ,总有效率为55 6% ,完全缓解率13 9% ,可评价毒性患者42例 ,白细胞减少发生率78 5% ,血红蛋白和血小板减少发生率分别为16 7 %和35 7% ,其它毒副作用少见。[结论]羟基喜树碱联合ELF方案治疗晚期胃癌疗效肯定 ,毒性较低 ,值得继续研究。更多还原

【Abstract】 To assess the antitumor efficacy and toxicity with the combination chemotherapy of hydroxyl camptothecin(HCPT),leucovorin(CF),fluorouracil(5 Fu) and etoposide(Vp16) in advanced gastric adenocarcinoma patient. Between June 1995 and July 1999,42 patients with gastric adenocarcinoma were treated with HCPT 40mg in the first and fifth day,CF 200mg/m2·d for 5 consecutive days iv,5 Fu 500mg/m2·d for 5 consecutive days iv and with Vp16 80mg/m2 ·d for consecutive days,every 3 weeks. Forty_two patients were evaluated for efficacy.The overall response rate was 55 6% and the complete response rate was 13 9% of the 36 patients evaluated for toxicity,leukopenia was observed in 78 5%,anemia and thrombocytopentia were observed in 16 7% and 35 7% of patients respectively,other side effects were uncommon.[Conclusions] HCPT,CF,5 Fu and Vp16 were effective for advanced gastric adenocarcinoma and worthy to be further studied.更多还原