【摘要】 目的研究Parkin基因5号外显子缺失与早发散发性帕金森病发病的关系。方法应用聚合酶链式反应(PCR)、琼脂糖电泳方法检测了60例早发性帕金森病病人外周血白细胞DNA的Parkin基因5号外显子缺失情况。结果发现1例病人(1.67%)存在Parkin基因5号外显子缺失。结论Parkin基因外显子缺失可能与部分早发性帕金森病发病有关。更多还原

【Abstract】 Objective To study the relation between etiology and exonic deletion on exon 5 of Parkin gene on sporadic early-onset Parkinson’s disease.Methods The deletion on exon 5 of Parkin gene was determined using PCR, agarose electrophoresis techniques in DNA of 60 sporadic Parkinson’s disease patients with an onset age early than 50. Results One (1.67%) exonic deletion of exon 5 was found among the 60 cases. Conclusion Exonic deletion of parkin gene is likely related to sporadic early-onset Parkinson’s disease.更多还原