【摘要】 目的 :本研究主要观察电针和兴奋尾核对苍白球神经元自发放电的影响 ,为进一步研究苍白球与针刺镇痛和兴奋尾核镇痛的关系及其机理提供某些实验资料。方法 :实验在Wistar大鼠和家猫上进行。采用玻璃微电极细胞外记录的方法记录苍白球神经元的自发放电 ,观察电针“阳陵泉”和“环跳”穴 (强度为 2mA ,频率为 2～ 10 0Hz的疏密起伏波 ,时间为 5min)及兴奋尾核头部 (微量注射 0 .5M谷氨酸 3μL)对自发放电的影响。结果 :电针可抑制苍白球外侧部神经元的自发放电 ,对内侧部自发放电略有兴奋作用 ;兴奋尾核也可抑制苍白球外侧部神经元的自发放电 ,而对内侧部自发放电影响不大。结论 :电针对苍白球神经元自发放电有一定的影响 ,可能与兴奋尾核有关更多还原

【Abstract】 Objective: To observe whether spontaneous discharges of neurons in the globus pallidus could be influenced by electroacupuncture or excitation of the caudate nucleus, so as to investigate further if the globus pallidus was involved in acupuncture and exciting caudate nucleus induced analgesia. Methods: The present experiments were performed on cats and Wistar rats. Spontaneous discharges of neurons in the globus pallidus were recorded by glass microelectrodes extracellularly. All animals received electroacupuncture of “Yanglingquan" (GB 34) and “Huantiao" (GB 30) points (3 mA, 2～100 Hz dense sparse waves, 5 min). Excitation of neurons in the caudate nucleus was achieved through microinjection of glutamate (0.5 M, 3 μL) into the nucleus. Results: We found that the spontaneous discharges of the neurons recorded in the lateral region of the globus pallidus could be inhibited by electroacupuncture , and those of the neurons recorded in the medial region of the globus pallidus could slightly be enhanced by electroacupuncture. Similar results were acquired through the excitation of the caudate nucleus. Conclusion: Electroacupuncture can influence spontaneous discharges of neurons in the globus pallidus, which may be related to the excitation of the caudate nucleus.更多还原