【摘要】 为观察红曲对高血压模型大鼠收缩压的影响 ,每日经口给予自发高血压大鼠 (SHR)、肾血管型高血压大鼠 (RHR)、DOCA 盐型高血压大鼠 (DHR) 0 0、0 4、0 8、1 2g kgBW红曲 3～ 4周 ,每周测量收缩压(SBP)一次。结果显示 ,红曲能够降低SHR、DOCA -盐型高血压大鼠的血压 (P <0 0 5 ) ,对RHR的降血压作用不明显 ,其中对DOCA 盐型高血压大鼠的降血压作用强于SHR更多还原

【Abstract】 The hypotensive effect of manascus was studied by using three well established rat models with hypertension: spontaneously hypertensive rat (SHR), renalvascular hypertensive rat (RHR, 2K1C) and DOCA salt hypertensive rat. Manascus of 0 0, 0 4, 0 8, 1 2 g/kg BW (p o) were administrated daily to these animals for 3-4 weeks. Systolic blood pressure (SBP) and heart rate were measured once a week by using tail cuff method.The hypotensive effect of manascus was observed in SHR and DOCA salt hypertensive rats; and the effect was more potent in DOCA salt hypertensive rat. Manascus showed less potential hypotensive effect in RHR.更多还原