【摘要】 目的　探讨尿激酶型纤溶酶原激活物受体 (u PAR)在人脑胶质瘤中的表达及其与临床病理分级的关系。方法　应用流式细胞仪定量检测 35例标本中u PAR含量 ,其中I级 8例 ,II级 9例 ,III级 9例 ,IV级 6例 ,正常脑组织 3例 ,染色应用直接染色法。结果　u PAR在人脑胶质瘤中的表达与病理分级相关 ,III级、IV级与I级、II级和正常脑组织相比较 ,差异有极显著的统计学意义 ,P值均小于 0 0 1。III级与IV级相比较 ,P <0 0 1;I级与II级相比较 ,P >0 0 5 ,差异没有统计学意义。结论　u PAR表达与病理分级相关 (r=0 83) ,可作为判断人脑胶质瘤恶性程度和浸润性能的指标。更多还原

【Abstract】 Objective: To investigate the pathologic significance of quantitation of urokinase type plasminogen activator receptor in human brain glioma. Methods: The specimens of 35 cases were quantitated by flow cytometry (FCM), including grade I 8, grade II 9, grade III 9, grade IV 6,and 3 normal brain tissues. Direct staining was used in this study. Results: The intensity of individual u PAR expression in human glioma was correlated with the pathologic grade, and quantitative assay showed that u PAR expression was higher in grade III and grade IV than that in grade I, grade II and normal brain. There was significant differences between them (P<0 01). The expression in grade IV was higher than that in grade III (P<0 01), and there was no significant difference between grade I and grade II (P>0 05). Conclusion: The expression of u PAR is positively correlated with the pathologic grade or pattern (r=0 83), and the expression of u PAR can be the index of judging the malignant degree and infiltrative ability.更多还原