【摘要】 目的　探讨血管紧张素Ⅱ受体拮抗剂氯沙坦在降血压同时对自发性高血压大鼠的肾脏保护作用及其机制。方法　观察氯沙坦对自发性高血压大鼠血压、尿微量白蛋白、转铁蛋白和α1微球蛋白的影响 ,以及肾脏组织中的血管紧张素Ⅱ (AngⅡ )、醛固酮 (Ald)、内皮素 (ET)的影响。 结果　氯沙坦可降低自发性高血压大鼠的血压 ,减少自发性高血压大鼠尿中微量白蛋白、转铁蛋白和α1微球蛋白的排出 ,降低肾组织局部醛固酮、ET的含量 ,但使局部血管紧张素Ⅱ水平升高。结论　氯沙坦对自发性高血压大鼠肾脏具有保护作用 ,此作用可能与氯沙坦阻断AngⅡ的作用 ,降低肾组织局部醛固酮、ET水平有关更多还原

【Abstract】 Objective To evaluate the protective effects of specific antagonists of angiotensin Ⅱ receptor Losartan on the kidneys of spontaneously hypertensive rats and study their mechanisms.Methods Blood pressure,urinary microalbumin,urinary microtransferrin and α 1 microglobulin protein were measured.Angiotensin Ⅱ,aldsterone and endothelins level of renal tissue were determined with radioimmunoannalysis.Results After treatment with losartan,the blood pressure of SHR was decreased,urinary microalbumin,urinary microtransferrin and α 1 microglobulin protein were reduced.Renal tissure ET,Ald concentration decreased after SHR receiving losartan level of Ang Ⅱ increased.Conclusion Losartan can protect the kidney of SHR.Interdiction of Ang Ⅱ and the decrease of ET,Ald concentration in renal tissue may be a mechanism for this action.更多还原