【摘要】 目的　探讨感染乙肝病毒 (HBV )的非霍奇金淋巴瘤患者的化疗方案。方法　回顾性分析 96例非霍奇金淋巴瘤(NHL )及 39例感染乙肝病毒的其它实体瘤 (肝癌除外 )患者化疗后肝损害及乙型肝炎的发生情况。结果　经过 2个周期正规化疗后 ,HBV阳性的NHL患者化疗后肝损害发生率为 5 2 .2 % (12 /2 3) ,HBV阴性的NHL患者化疗后肝损害发生率 2 3 .3 % (17/73) ,P <0 .0 1;HBV阳性的NHL患者用含有类固醇激素方案化疗后乙型肝炎发生率 39.1% (9/2 3) ,HBV阳性的其它实体瘤 (肝癌除外 )患者用不含类固醇激素方案化疗后乙型肝炎发生率 12 .8% (5 /39) ,P <0 .0 5。结论　HBV阳性的NHL患者化疗后易发生肝损害及乙型肝炎 ,故在化疗时应尽量避免选用含皮质激素的方案更多还原

【Abstract】 Objective To inquire into the choose of chemotherapy in lymphoma patients with serum positive hepatitis B virus(HBV) marker.Methods Liver damage and hepatitis induced by the chemotherapy retrospectively were analysed in 96 cases of Non Hodgkin’s lymphoma(NHL) and 39 cases of other solid tumor except liver cancer.Results After two cycles of chemotherapy,the rate of liver damage was 52.2%(12/23) in NHL with HBV(+) group and 23.3%(17/73) in HBV(-) group( P <0.01);the rate of hepatitis was 39.1%(9/23) in NHL with HBV(+) after steroids containing chemotherapy and 12.8%(5/39) in other solid tumor with HBV(+) after steroids free chemotherapy( P <0.05).Conclusion For the NHL patient with HBV infection,the steroids free chemotherapy regimen will be optimal choice.更多还原