【摘要】 采用二次样条小波变换提取心电信号的特征点 ,并通过分析羊心脏表面 64通道的心电信号 ,研究心肌缺血前后的兴奋恢复间隔 ( Activation- recovery interval,ARI)及其离散度的变化 ,发现当缺血造成心室复极不一致增大时 ,心脏表面的平均 ARI没有明显的变化 ,而 ARI离散度明显增加 ( 5 9.9ms vs12 6.3 ms,P=0 .0 0 0 7) ,进一步的计算机模拟证明 ARI接近动作电位时程 ,表明 ARI离散度可能是一个能表征心室复极不一致的有效参数更多还原

【Abstract】 The aim of this study was to investigate whether ARI (activation recovery interval) dispersion on the sheep epicardium was related with the ischemia induced heterogeneity in ventricular repolarization. We have developed an algorithm based on wavelet transformation to analyze ARI from a 64 channel epicardial ECG data of an ischemic sheep. The quadratic spline wavelet was used to extract QRS with 2 1 scale and T wave with 2 5 scale, and then A and R points were determined by definition. It was found that there was not a significant difference in the average ARI on the epicardium before and during ischemia. Meanwhile ARI dispersion on the epicardium was significantly increased during ischemia (126.3 ms vs 59.9 ms, P =0.0007). Furthermore,a computer simulation showed that ARI is very close to ADP, suggesting that ARI dispersion may be an effective parameter to estimate the heterogeneity in ventricular repolarization induced by ischemia.更多还原