【摘要】 目的 :探讨早期生长反应基因 - 1(Egr- 1)在小鼠和人体正常组织细胞中的表达情况及其生理学功能。方法 :用原位杂交和免疫组织化学方法对小鼠和人的不同组织进行Egr- 1检测。结果 :Egr- 1mRNA和Egr - 1蛋白阳性信号呈棕褐色 ,位于细胞浆和细胞核。组织中生长活跃的细胞可见相对高水平的Egr- 1表达。结论 :Egr- 1mRNA和Egr - 1蛋白的高表达主要在生长活跃的组织并有重要的生理学功能更多还原

【Abstract】 Objective: To study the expression of early growth response gene-1(Egr-1) in normal mouse and human tissues and its physiologic function. Methods: In-situ hybridization and immunohistochemistry were used respectively to detect Egr-1mRNA and protein in different tissues of mouse and human.Results:Egr-1 mRNA and Egr-1 protein positive signals were brown in color, located in cytoplasm and nucleus. Egr-1 expression had relatively high level in active growth cells. Conclusion: The expressions of Egr-1 mRNA and Egr-1 protein are mainly in active growth tissues and play an important physiologic function.更多还原