【摘要】 用分离纯化的大豆和丹贝异黄酮的5个单位Genistein.Daidzein. Glycitein. Genistin . Daidzin分别作用于乳腺癌MCF－7细胞株、子宫癌Hela细胞株和卵巢癌HO－8910细胞株，研究各单位对各种癌细胞株的抑制率和IC₅₀值。结果Genistein在1.00E－04（mol/L）时对乳腺癌MCF－7细胞株抑制率为63％；IC₅₀=8.47E－05，对子宫癌Hela细胞株的抑制率为58.04％；IC₅₀IC50=9.45E－05，对卵巢癌HO－8910细胞株的抑制率为67.70％；IC₅₀=8.87E－05，Daidzein在1.00E－04（mol/L）浓度时对卵巢癌HO－8901细胞株的抑制率为67.70％；IC₅₀=2.62E－05。更多还原

【Abstract】 Tdoetermine Tempeh is oflavones inhibition on humabreast, uterus and ovary casncer cells. Thress cancer cells including MCF－7、Hela、Ho－8901 were treated by genistein、daidzein、glycitein、genistin、daidzin respectively, measuring the rate of inhibition and IC₅₀. Genistein at 1.00E－04mol/L plrovided 63.08％rate of inhibition and IC₅₀IC50=8.47E－05 in breast cancer MCF－7 cell、58.042％rate of inhibition and IC₅₀=9.45E－05 in uterus cancer Hela cell、67.70％rate of inhibition and IC₅₀=8.890E－05 in ovary cancer HO－8910 cell, respectively. Daidzein at 1.00E－04mol/L produced 67.70％control and IC₅₀=2.62E－05 over ovary cancer HO－8910 cell.Tempeh isoflavone had higher antitumor activity than soybean isoflavone. Genistein showed has the higher control. Daindzein had effect only on ovary cancer cell. Genistin and Daidzintogethek showed no effect on three cancer cell.更多还原