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冠心病心绞痛病人血浆t-PA及其抑制物活性的测定
A STUDY ON THE DETERMINATION OF PLASMA t-PA AND PAI ACTIVITY IN CORONARY HEART DISEASE PATIENTS WITH ANGINA PECTORIS
【摘要】 ①目的 探讨冠心病心绞痛病人血浆组织型纤溶酶原激活物 (t PA)及其抑制物 (PAI)活性的变化及其可能机制。②方法 采用显色底物法对 2 0例冠心病心绞痛病人和 2 0例健康人血浆t PA及PAI的活性进行测定。③结果 心绞痛病人血浆t PA活性显著低于对照组 (t =3 .87,P <0 .0 1) ,PAI活性明显高于对照组 (t =2 .6 3 ,P <0 .0 5 ) ,6 5岁以上老年病人上述指标的异常变化尤为显著 (t=3.87,2 .98,P <0 .0 1)。④结论 冠心病心绞痛病人存在纤溶系统功能异常 ,有可能在冠状动脉粥样硬化的基础上形成血栓
【Abstract】 Objective To investigate the plasma tissue-type plasminogen activator(t-PA) and plasminogen activator inhibitor(PAI) in coronary heart disease patients with angina pectoris and its probable mechanism.\ Methods The plasma t-PA and PAI activity of coronary artery disease patients with angina pectoris were measured. \ Results The t-PA activity of the patients significantly decreased (t=3.87,P<0.01),and the PAI significantly higher than that of the healthy controls(t=2.63,P<0.05). The abnormal changes of the t-PA and PAI in patients more than 65 years old were more significant.\ Conclusion The patients with angina pectoris may have abnormal fibrinolysis and cause thrombosis on the basis of arteriosclerosis.
【Key words】 angina pectoris; alteplase; plasminogen activator inhibitor;
- 【文献出处】 齐鲁医学杂志 ,Medical Journal of Qilu , 编辑部邮箱 ,2001年02期
- 【分类号】R541.4
- 【被引频次】6
- 【下载频次】24