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冠心病心绞痛病人血浆t-PA及其抑制物活性的测定

A STUDY ON THE DETERMINATION OF PLASMA t-PA AND PAI ACTIVITY IN CORONARY HEART DISEASE PATIENTS WITH ANGINA PECTORIS

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【作者】 王珍林淑美章政王晓林

【Author】 WANG Zhen, LIN Shumei, ZHANG Zheng, et al\ Department of Special Medical Care, The Affiliated Hospital of Qingdao University Medical College, Qingdao 266003

【机构】 青岛大学医学院附属医院特需病房!青岛266003

【摘要】 ①目的 探讨冠心病心绞痛病人血浆组织型纤溶酶原激活物 (t PA)及其抑制物 (PAI)活性的变化及其可能机制。②方法 采用显色底物法对 2 0例冠心病心绞痛病人和 2 0例健康人血浆t PA及PAI的活性进行测定。③结果 心绞痛病人血浆t PA活性显著低于对照组 (t =3 .87,P <0 .0 1) ,PAI活性明显高于对照组 (t =2 .6 3 ,P <0 .0 5 ) ,6 5岁以上老年病人上述指标的异常变化尤为显著 (t=3.87,2 .98,P <0 .0 1)。④结论 冠心病心绞痛病人存在纤溶系统功能异常 ,有可能在冠状动脉粥样硬化的基础上形成血栓

【Abstract】 Objective To investigate the plasma tissue-type plasminogen activator(t-PA) and plasminogen activator inhibitor(PAI) in coronary heart disease patients with angina pectoris and its probable mechanism.\ Methods The plasma t-PA and PAI activity of coronary artery disease patients with angina pectoris were measured. \ Results The t-PA activity of the patients significantly decreased (t=3.87,P<0.01),and the PAI significantly higher than that of the healthy controls(t=2.63,P<0.05). The abnormal changes of the t-PA and PAI in patients more than 65 years old were more significant.\ Conclusion The patients with angina pectoris may have abnormal fibrinolysis and cause thrombosis on the basis of arteriosclerosis.

  • 【文献出处】 齐鲁医学杂志 ,Medical Journal of Qilu , 编辑部邮箱 ,2001年02期
  • 【分类号】R541.4
  • 【被引频次】6
  • 【下载频次】24
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