【摘要】 22℃室温中的长爪沙鼠血清T3 和T4 浓度较低 ,肝脏和褐色脂肪组织 (BAT)的T45 脱碘酶活力也较低。冷暴露 ( 4℃ ) 1d后 ,血清T3与T4 浓度迅猛增长 ,随后 1～ 4周的冷驯化中 ,T3缓慢上升 ,T4 逐渐下降 ,肝脏和BAT的T4 5 脱碘酶活力变化与血清T3 和T3/T4 变化一致。表明冷驯化激活了甲状腺功能 ,激活了外周组织中的甲状腺激素代谢。更多还原

【Abstract】 There were low serum T 3 and T 4 concentration and the activities of T 4 5 deiodinase in liver and brown adipose tissue (BAT) in Mongolian gerbil( Meriones unguiculatus ), at 22±2℃ of room. Serum T 3 and T 4concentration increased rapidly after cold exposure (4±2℃) for 1 day, both of which showed as 340% and 208% high , respectively, as those in warm. Following cold acclimation from 1 week to 4 weeks, serum T 3 level rose slowly and T 4 decreased slowly, leading to the increase of T 3/T 4. The changes in T 4 5 deiodinase activities of BAT and liver were similar to those of serum T 3 and T 3/T 4 during cold exposure. These results indicated that thyroid activity and the metabolism of thyroid hormone in peripheral tissue were activated by cold acclimation in Mongolian gerbil, which may take part in regulation of basal metabolic rate and nonshivering thermogenesis.更多还原