【摘要】 用 HPL C-ECD法对 APP695 ,75 1 V71 7I转基因模型小鼠大脑皮层神经递质进行检测 ,结果显示 APP75 1转基因鼠大脑皮层中的 5 -HIAA含量与对照组比较有显著性差异。APP695转基因鼠大脑皮层中 DA和 5 -HT平均含量分别比对照鼠升高 3 8.9%和 45 .8%。提示 Aβ的形成可能影响了多巴胺系统和 5 -羟色胺系统。更多还原

【Abstract】 Alzheimer’s disease(AD) is a progressive neurodegenerative disease. It is known that AD is associated with some neuotransmitters disorder. We examine the monoamine transmitter in neuons of forebrain by HPLC-ECD method. The content of the 5-HIAA in APP amyloid precursor protein 751 trangenic mice show significant difference compared with that of the control group. The content of the DA and 5-HT in APP695 transgenic mice increased 38.9% and 45.8% respectively compared with control group. It suggested that the DA and 5-HT system may be affected respectively by Aβ.更多还原