【摘要】 基于CD8+ T记忆细胞的线性和逆线性分化假说分别建立了数学模型 ,并研究了各种T细胞亚类的动力学 .发现在优化剂量抗原入侵的条件下 ,两个模型均能产生记忆 ,并可较好地模拟实验结果 .通过进一步模拟发现CD8+ T细胞记忆与抗原的存在紧密相关 ,再次证实了抗原在维持T细胞记忆中的作用 .另外还讨论了记忆细胞寿命的问题 .认为逆线性假说具有更强的反应性和记忆性更多还原

【Abstract】 Based on the linear and reverse linear differentiation models of CD8 + memory T cells, mathematical models were set up respectively and the dynamics of different T subpopulations was studied. It was found that when invading antigen with optimal dose of, both models can generate memory and fit well with experimental data. Further study found that CD8 + T cell memory relates strongly to the persistence of antigen. Thus the contribution of antigen to maintenance of T cell memory is reconfirmed. The effect of the life span of memory cells on immune memory was also investigated. Reverse linear differentiation model is deemed to have advantage in generation of immune response and memory.更多还原