【摘要】 为探讨血清IV型胶原 (IV C)和层粘连蛋白 (LN)在系统性红斑狼疮 (SLE)患者中的临床意义 ;我们采用放射免疫法(RIA)对 34例SLE和 6 3例正常人的血清IV C和LN含量进行了测定 ,并进行治疗前后对比以及血清IV C和LN水平与其它临床指标间的直线相关关系分析。结果发现SLE组血清IV C和LN均较对照组显著升高 (P <0 0 0 0 1) ;治疗后随病情缓解较治疗前明显降低 (分别为P <0 0 0 1;0 0 0 5 )。血清LN与血清白蛋白呈显著负相关 (P <0 0 0 1) ,与 2 4h尿蛋白定量、血清免疫球蛋白M和补体C3水平之间呈明显的正相关 (P <0 0 5 ) ;血清IV C与血沉呈显著正相关 (P <0 0 5 )。上述结果提示血清IV C和LN水平在SLE患者中普遍升高 ,是评估SLE患者病情活动的重要指标更多还原

【Abstract】 To explore the clinical value of laminin (LN) and collage IV(IV C) in sera of patients with systemic lupus erythematosus (SLE),a sensitive radioimmunoassay was utilized to detect the level of IV C and LN in sera of 34 patients with SLE and 63 with normal It was found that the levels of IV C and LN in SLE elevated significantly and were obviously higher than that in normal( P <0 0001) and after therapy the level of IV C and LN in SLE were significantly reduced ( P <0 001;0 005) There is a negative correlation between sera LN and albumin ( P <0 001),a positive correlation between sera LN and immunoglobulin M,complement C3 and amount of proteinuria in 24 hours ( P <0 05),a positive correlation between sera IV C and erythrocyte sedimentation rate ( P <0 05) These results showed sera IV C and LN were generally increased in SLE and may be important reference factors in evaluating the activity of SLE更多还原