【摘要】 目的 :研究血管内皮生长因子 (VEGF)及其受体在卵巢癌组织中的表达及临床意义。方法 :应用免疫组化SABC法 ,检测 33例上皮性卵巢癌、10例良性卵巢肿瘤、10例正常卵巢组织中VEGF及其受体VEGFR 1、VEGFR 2的表达 ,用Ⅷ因子单抗标记肿瘤新生血管内皮 ,计数微血管密度 (MVD)。结果 :VEGF及其受体VEGFR 1、VEGFR 2的表达在卵巢癌组织中显著高于良性及正常卵巢组织 (P <0 .0 5) ,且与卵巢癌患者临床分期、淋巴结转移、腹水癌细胞阳性、盆腔内形成粘连、MVD有明显相关性 (P <0 .0 5)。结论 :VEGF及其受体是卵巢癌重要的血管生成调节系统 ,与卵巢癌发生、发展密切相关 ,以VEGF及其受体为靶点的抗血管生成疗法对卵巢癌是可行的。更多还原

【Abstract】 Objective:To study the expression and clinical significance of vascular endothelial growth factor (VEGF) and its receptors in epithelial ovarian cancer.Methods:SABC immunohistochemical method was used to investigate the expression of VEGF and its receptors in 33 samples of epithelial ovarian cancers(EOC),10 samples of benign tumors and 10 samples of normal ovarian tissue and MVD was counted with factor Ⅷ mono clone antigen as markers of newborn blood vessles.Results:The expression of VEGF and its receptors in EOC was significantly higher than that in benign and normal ovarian tissues(P<0.05).The expression rates were associated with clinical stage and lymphnode metastasis and ascites tumor cell and pelvic adhesion and MVD(P<0.05).Conclusion:VEGF and its receptors are the important angiogenetic regulating system in EOC,correlated with the occurrence and development of EOC.It’s feasible to treate EOC with antiangiogenesis therapy targeting VEGF and its receptors.更多还原