【摘要】 目的 :探讨内皮素 (ET)在蛛网膜下腔出血 (SAH)发生发展中的作用。方法 :采用放射免疫分析法检测 36例SAH患者血浆ET浓度。结果 :①SAH组ET含量为 (12 7.4 5± 11.30 )ng/L ,明显高于对照组的 (6 6 .75± 7.2 3)ng/L(P <0 .0 0 1) ;②血浆ET浓度动态变化规律 :发病 2 4h内开始升高 ,半月内持续偏高 (4～ 7d达高峰 ) ,之后下降 ,发病 1月后恢复正常 ,与SAH后脑血管痉挛 (CVS)的时程相一致 ;③有症状性血管痉挛者ET含量为 (16 6 .4 2± 12 .12 )ng/L明显高于无症状性血管痉挛者的 (96 .86± 10 .0 8)ng/L(P <0 .0 0 1) ;④血浆ET浓度与病情轻重及是否合并其他脏器损害有关 :重型为 (16 1.6 3± 12 .80 )ng/L ,明显高于轻型的 (99.96± 6 .0 8)ng/L(P <0 .0 0 1) ;合并其他脏器损害者为 (155.33± 11.15)ng/L明显高于单纯SAH的 (10 3.0 5± 12 .53)ng/L(P <0 .0 0 1)。 结论 :内皮素在SAH的发生发展尤其是在SAH后的CVS中起着重要的作用 ,测定其浓度有助于判断病情预后更多还原

【Abstract】 Objective:To investigate the role of enothelin(ET) in patients with subarachnoid hemorrhage(SAH).Methods:The changes of ET in plasma of 36 patients with SAH was observed by radioimmunoassay.Results:①The levels of ET in SAH group 〔(127.45±11.30)ng/L〕 were higher than those of normal group〔(66.75±7.23)ng/L〕 significantly(P<0.001).②The levels of ET in SAH group elevated in 24 hours,and lasted for 15d(reaching the peak during 4～7d),then began to descend and recovered to normal level 30d later after the onset of SAH.③The levels of ET in SAH with cerebral vasospasm(CVS) 〔(166.42±12.12)ng/L〕 were significantly higher than those of without CVS 〔(96.86±10.08)ng/L〕 (P<0.001).Conclusion:ET plays a key role in the pathogenesis of SAH and can be used as an important prognosis indicator.更多还原