【摘要】 目的 :探索检测肿瘤标志物铁蛋白 (SF)、甲胎蛋白 (AFP)、癌胚抗原 (CEA)及 β2 微球蛋白 ( β2 M )对各种恶性肿瘤诊断及预后估计的价值。方法 :应用放射免疫法检测近 4年来在我科住院的 2 78例肿瘤患者的空腹静脉血 ,测定其SF、AFP、CEA、β2 M的血清值。结果 :乳腺癌、子宫内膜癌、鼻咽癌、壶腹癌等患者不论分期如何 ,此 4项肿瘤标志物检测值均在正常范围 ,其他肿瘤Ⅱ期以下患者 4项检测值亦在正常范围。Ⅲ期患者 (肝癌患者除外 ) 4项标志物的平均阳性率为 8% ,Ⅳ期患者 4项标志物的平均阳性率为 38 4 % ,显著高于Ⅲ期患者 (P <0 .0 1)。肿瘤组与对照组 4项肿瘤标志物的总平均阳性率分别为 30 %与 3 9% ,差异有极显著性 (P <0 .0 1)。结论 :此 4项肿瘤标志物对恶性肿瘤的诊断有一定价值 ,且对肿瘤患者的病情监测有一定意义。更多还原

【Abstract】 objective To investigate the value of ferritin(SF),a fetal protein(AFP),carcinoembryonic antigen(CEA) and β 2 mictroglobulin(β 2 M) in diagnose of malignant tumors.Methods Radio immune Assay(RIA) was used to examine serum SF,AFP,CEA,β 2 M in 278 tumor patients in last 4 years.Results Four tumor markers in patients of mammary carcinoma,endometrial carcinoma,nasopharyngcal carcinoma or ampulla cancer are normal,no matter which period they were.The four tumor markers’value in other tumor patients under Ⅱ phase was also normal.In phase Ⅲ patients except liver cancer ones,the average positive rate of 4 markers is only 8%.The average positive rate of 4 markers in phase Ⅳ patienst is 38.4%,which is higher than Ⅲ phase patients significantly ( P <0.01).The total average positive rate of four tumor markers in tumor group and control group are 30% and 3.9%,respectively,with significant difference ( P <0.01).Conclusion The four tumor markers are valuable in diagnosis of malignant tumors and in monitoring of disease development.更多还原