【摘要】 目的 :阐明肥胖低通气综合征 (OHS)所致急性呼吸衰竭的临床特点。方法 :对 8例OHS致急性呼吸衰竭患者的临床和实验室检查资料进行分析。结果 :7例男性和 1例女性患者均表现为肥胖 ,体重指数 (BMI)女性为 38.79kg·m-2 ,男性平均 42 .68kg·m-2 ,年龄平均 62岁。全部患者均表现有呼吸性酸中毒 ,平均pH 7.19,平均动脉血二氧化碳分压(PaCO2 ) 12 .35kPa ,平均动脉血氧分压 (PaO2 ) 5 .40kPa。 8例肺功能检查显示第 1秒用力呼气容积实测值占预计值的百分比(FEV1% )为 78.75 % ,肺活量实测值占预计值的百分比 (VC % )为 78.80 %。经治疗后PaCO2 为 6.49kPa ,PaO2 为 11.42kPa。结论 :OHS导致急性呼吸衰竭发生快 ,表现多样 ,肺功能损害轻 ,治疗及时则预后较好。更多还原

【Abstract】 Objective To study the clinical features of acute respiratory failure induced by obesity hypoventilation syn~drome(OHS).Method Clinical and laboratory features of 8 patients were reviewed.Results 8 patients(7 male,1 female)with obesity presented a BMI of 38.79 kg·m -2 in female and 42.68?kg·m -2 in male.The mean age of the patients was 62 years old.They all had respiratory acidosis(mean pH?7.19),hypercapnia(mean PaCO 2?12.35?kPa),and hypoxemia(mean PaO 2?5.40?kPa).Pulmonary function test showed that the forced expiratory volume in one second to forced vital capacity ratio(FEV 1%) was 78.75 % and the vital capacity ratio(VC%) was 78.80%.During period of clinical stability all had awake hypercapnia (mean PaCO 2?6.49?kPa),and hypoxemia(mean PaO 2?11.42?kPa).Conclusion Acute respiratory failure induced by OHS has a sudden onset,various presentation and a little lesion to pulmonary function so it can be reversed with early and proper treatment.更多还原