【摘要】 目的 :探讨静脉注射硫酸镁迅速提高血镁至双倍生理浓度的最佳剂量和耐受性 ,为开展硫酸镁脑保护治疗提供依据。方法 :将发病 72小时内的急性脑卒中病人 2 4例 ,随机分为 4组 :硫酸镁负荷量 12 mmol、 16 mmol、2 0 mmol+维持量 40 ml及安慰剂对照组。观察心率、血压、呼吸、血清镁浓度及 3周后神经功能缺损评分。结果 :硫酸镁负荷量 2 0 mmol能全部迅速达到理想血镁浓度 ,但未能维持此浓度至 2 4小时。绝大多数病人耐受性良好 ,1例出现血压过低。结论 :静脉注射硫酸镁以迅速升高血镁至理想浓度 ,对急性脑血管病人具有良好的耐受性和安全性。负荷量2 0 mmol可使血镁迅速达到理想水平 ,但维持量 40 mmol/ 2 4小时 ,不足以保持有效血浓度更多还原

【Abstract】 Abstract: This study was undertaken to optimize the regimen of intravenous Mg SO4 after acute stroke. Methods: Within 72 hours of the onset of stroke, patients were randomized to receive placebo or one of three intravenous Mg SO4 infusions: a loading infusion of 12, 16, or 20mmol, followed by 40mmol over 24 hours. Cardiovascular parameters, respiration rate and serum magnesium concentrations were determined. Outcome at 3 weeks was recorded. Result: 23 patients were recruited and treated at a median time of 22.5 hours after stroke. Almost no tolerability problems were idemtified. No effects of magnesium on heart rate, blood pressure, or respiration rate were evident except one who probably high sensitively. Serum magnesium concentration of all patient rose to target levels rapidly in the highest loading infusion group, but no one cen be maintained at 24 hours. Conclusions: Mg SO4 infusions that rapidly elevate the serum magesiun concentration to target levels are well tolerated and have little major hemodynamic effects in patients with acute stroke. The 20mmol loading infusion should be chosen for further trails, but followed by 40mmol/24 hours was not sufficient.更多还原